Department of Surgery, CUHK


Team 1 is the Hepatobiliary and Pancreatic Surgery Division of the Department of Surgery in Prince of Wales Hospital, which is also the teaching hospital of the Chinese University of Hong Kong. Currently it consists of two professors, one clinical professional consultant two consultants, three associate consultants, one specialist residents, three surgical trainees and two surgical interns. It also has one research assistant. The main operation area consists of wards 8A, 8B and 8C. Day case patients will be admitted to ward 10LM. Patients may also be cared in intensive care unit or private ward as appropriate. The outpatient Team 1 clinic is at 2/F North Wing of Li Ka Shing Outpatient Clinic. Most operations would be carried out in Prince of Wales Hospital while in some selected cases, operations will be done in Alice Ho Miu Ling Nethersole Hospital as day surgery or short stay surgery. Apart from providing clinical service to general surgical patients and patients with hepatobiliary and pancreatic diseases, Team 1 also provides teaching to medical students of the Chinese University of Hong Kong and carries out both clinical and scientific research.


Team 1 is one of the three general surgery teams within the department. Like other general surgery teams, Team 1 deals with general surgical cases like hernia, cutaneous lumps and bumps. It also receives emergency surgical cases such as acute appendicitis and perforated peptic ulcers. On the other hand, Team 1 needs to take care of patients with surgical diseases of the liver, biliary tract and pancreas in the New Territories East Cluster.

The main bulk of elective work of Team 1 involves the treatment of liver malignancies in terms of liver resection or local ablation therapy. It also collaborates with the interventional radiologist for transarterial therapy for primary liver cancer. In addition to simple cholecystectomy, Team 1 also deals with complicated gallbladder and biliary tract diseases like choledochal cysts, Mirizzi Syndrome and bile duct tumors. Surgical treatment of pancreatic tumors is also included in our service with predominately pancreaticoduodenectomy and distal pancreatectomy as our major scope of work.

Team 1 is also involved in endoscopic retrograde cholangiopancreatography (ERCP) and endoscopic ultrasound (EUS) as diagnostic and therapeutic endoscopic procedures provided to our patients.

Collaboration with other specialties:

  • Joint Hepatoma Clinic - a multidisciplinary approach with oncologist and radiologist for care of hepatoma patients.
  • Combined meeting with hepatologist, oncologist and radiologist for research and inter-department collaboration project.
  • Combined pancreatic cancer meeting with gastroenterologist, radiologist and oncologist on management and research on pancreatic cancer.


  • Establishment of a liver function assessment center to facilitate the pre-operative workup and assessment for patients undergoing hepatectomy
  • Establish the use of no-clamp hepatectomy with low central venous pressure as the standard liver resection technique
  • Development of minimally invasive approach for liver resection: laparoscopic and robotic hepatectomy
  • Development of new local ablation technology for liver tumors: radiofrequency and microwave ablation
  • Adoption of pre-operative portal vein embolization as an adjunct for patients with small future liver remnant
  • Adoption of fibroscan as a pre-hepatectomy liver function assessment tool
  • Development of minimally invasive surgery for pancreatectomy: laparoscopic and robotic approach
  • Development of single incision laparoscopic cholecystectomy
  • Maintain a low mortality and low morbidity for both hepatectomy and pancreatectomy


  • Open liver resection with or without vascular inflow occlusion for hepatocellular carcinoma: a randomized controlled trial
  • Microwave versus radiofrequency ablation for hepatocellular carcinoma: a prospective randomized control trial
  • Randomized controlled trial on adjuvant transarterial chemoembolization after curative hepatectomy for hepatocellular carcinoma (A-TECH trial)
  • A phase II single arm, multi-centre study of Bevacizumab (Avastin®) pre- and post-transarterial chemoembolisation (TACE) treatment for localized unresectable hepatocellular carcinoma (HCC)
  • Phase 2 study on safety and efficacy of irreversible electroporation for inoperable hepatic and pancreatic malignancy
  • A randomized controlled trial of endoscopic biliary radiofrequency ablation of malignant distal common bile duct strictures
  • Randomized multi-center study comparing no drainage to preoperative biliary drainage using metal stents in patients with resectable pancreatic or periampullary cancer
  • A study to evaluate the impact of liver stiffness on treatment outcome of unresectable hepatocellular carcinoma
  • A phase II study to evaluate the efficacy and biomarker of pegylated recombinant human arginase 1 ( PEG-BCT-100) for advanced hepatocellular carcinoma
  • Safety and tumoricidal effect of low dose temoporfin photodynamic therapy in patients with inoperable bile duct cancers (Foscan Study)

Academic Staff
Professor LAI Bo San Paul Professor
Professor CHOK Siu Ho Kenneth Professor
HA Staff
Dr LEE Kit Fai Consultant Advancement Exercise
Dr WONG John Consultant
Dr LOK Hon Ting Consultant
Dr CHONG Ching Ning Charing Associate Consultant
Dr FUNG Kai Yip Andrew Associate Consultant
Dr KUNG Wui Cheung Janet Associate Consultant
Dr KWOK Chun Pong Daniel Resident
Dr IP Ki Fung Shavonne Resident
Dr CHAN Chi Fung Resident
Dr LO Tsz Hin Resident


  • Lee KF, Wong RHL, Leung HHW, Lo EYJ, Chong CCN, Chan AWH, Lai PBS.
    En bloc transdiaphragmatic lung resection for locally advanced hepatocellular carcinoma: a case report.
    J Surg Case Rep. 2020 Jun 15;2020(6):rjaa084. doi: 10.1093/jscr/rjaa084. eCollection 2020 Jun.
  • Chong CCN, Lakhtakia S, Nguyen N, Hara K, Chan WK, Puri R, Almadi MA, Ang TL, Kwek A, Yasuda I, Doi S, Kida M, Wang HP, Cheng TY, Jiang Q, Yang A, Chan AWH, Chan S, Tang R, Iwashita T, Teoh AYB.
    Endoscopic ultrasound-guided tissue acquisition with or without macroscopic on-site evaluation: randomized controlled trial.
    Endoscopy. 2020 Jun 4. doi: 10.1055/a-1172-6027. Online ahead of print.
  • Chan TT, Chan WK, Wong GL, Chan AW, Nik Mustapha NR, Chan SL, Chong CC, Mahadeva S, Shu SS, Lai PB, Chan HL, Wong VW.
    Positive Hepatitis B Core Antibody Is Associated With Cirrhosis and Hepatocellular Carcinoma in Nonalcoholic Fatty Liver Disease.
    Am J Gastroenterol. 2020 Jun;115(6):867-875. doi: 10.14309/ajg.0000000000000588.
  • Gong Z, Yu J, Yang S, Lai PBS, Chen GG.
    FOX transcription factor family in hepatocellular carcinoma.
    Biochim Biophys Acta Rev Cancer. 2020 May 11;1874(1):188376. doi: 10.1016/j.bbcan.2020.188376.
  • Fung AKY, Chong CCN, Lai PBS.
    ERAS in minimally invasive hepatectomy.
    Ann Hepatobiliary Pancreat Surg. 2020 May 31;24(2):119-126. doi: 10.14701/ahbps.2020.24.2.119.
  • Yu S.C.H., Hui J.W.Y., Chong C.C.N., Chu C.M., Cheung S., Wong J., Lee K.F.
    Transarterial ethanol ablation for small hepatocellular carcinoma (≤ 3cm): A comparative study versus radiofrequency ablation.
    CardioVascular and Interventional Radiology 2020;43:732-739
  • Søreide K, Hallet J, Matthews JB, Schnitzbauer AA, Line PD, Lai PBS, Otero J, Callegaro D, Warner SG, Baxter NN, Teh CSC, Ng-Kamstra J, Meara JG, Hagander L, Lorenzon L.
    Immediate and long-term impact of the COVID-19 pandemic on delivery of surgical services.
    Br J Surg. 2020 Apr 30:10.1002/bjs.11670. doi: 10.1002/bjs.11670.
  • Ren J, Liu Y, Wang S, Wang Y, Li W, Chen S, Cui D, Yang S, Li MY, Feng B, Lai PBS, Chen GG.
    The FKH domain in FOXP3 mRNA frequently contains mutations in hepatocellular carcinoma that influence the subcellular localization and functions of FOXP3.
    J Biol Chem. 2020 Apr 17;295(16):5484-5495. doi: 10.1074/jbc.RA120.012518.
  • Cucchetti A, Zhong J, Berhane S, Toyoda H, Shi K, Tada T, Chong CCN, Xiang BD, Li LQ, Lai PBS, Ercolani G, Mazzaferro V, Kudo M, Cescon M, Pinna AD, Kumada T, Johnson PJ.
    The chances of hepatic resection curing hepatocellular carcinoma.
    J Hepatol. 2020 Apr;72(4):711-717. doi: 10.1016/j.jhep.2019.11.016.
  • Chan SL, Wong LL, Chan KA, Chow C, Tong JH, Yip TC, Wong GL, Chong CC, Liu PH, Chu CM, Wong VW, To KF, Reeves HL, Chan AW.
    Development of a Novel Inflammation-Based Index for Hepatocellular Carcinoma.
    Liver Cancer. 2020 Apr;9(2):167-181. doi: 10.1159/000504252. Epub 2019 Nov 21.
  • Wang N, Li MY, Liu Y, Yu J, Ren J, Zheng Z, Wang S, Yang S, Yang SL, Liu LP, Hu BG, Chong CC, Merchant JL, Lai PB, Chen GG.
    ZBP-89 negatively regulates self-renewal of liver cancer stem cells via suppression of Notch1 signaling pathway.
    Cancer Lett. 2020 Mar 1;472:70-80. doi: 10.1016/j.canlet.2019.12.026.
  • Liu YH, Lo EYJ, Lee KF, Chog CCN, Lai PBS.
    An unusual cause of upper gastrointestinal bleeding due to recurrent hepatocellular carcinoma: a case report.
    Int J Surg Case Rep 2020;70:83-86.
  • Liu M, Zhou J, Liu X, Feng Y, Yang W, Wu F, Cheung OK, Sun H, Zeng X, Tang W, Mok MTS, Wong J, Yeung PC, Lai PBS, Chen Z, Jin H, Chen J, Chan SL, Chan AWH, To KF, Sung JJY, Chen M, Cheng AS.
    Targeting monocyte-intrinsic enhancer reprogramming improves immunotherapy efficacy in hepatocellular carcinoma.
    Gut. 2020 Feb;69(2):365-379. doi: 10.1136/gutjnl-2018-317257. Epub 2019 May 10. PMID: 31076403.
  • Lee KF.
    Is robot necessary for left lateral sectionectomy?
    Laparosc Surg 2020;4:32
  • Jiang P., Sun K., Peng W., Cheng S.H., Ni M, Yeung P.C., Heung M.M.S., Xie T., Shang H., Zhou Z., Chan R.W.Y., Wong J., Wong V.W.S., Poon L.C., Leung T.Y., Lam W.K. J., Chan J.Y.K., Chan H.L.Y., Chan K.C.A., Chiu R.W.K., Lo Y.M.D.
    Plasma DNA end-motif profiling as a fragmentomic marker in cancer, pregnancy and transplantation.
    Cancer Discovery 2020;10(5):664-673
  • Chong C.C.N., Lok H.T., Fung A.K.Y., Fong A.K.W., Cheung Y.S., Wong J., Lee K.F., Lai P.B.S.
    Robotic versus laparoscopic hepatectomy: application of the difficulty scoring system.
    Surgical Endoscopy 2020;34:2000-2006
  • Chong C.C.N., Lee K.F., Cheung S.Y.S., Chu C.C.M., Fong A.K.W., Wong J., Hui J. W.Y., Fung A.K.Y., Lok H.T., Lo E.Y.J., Chan S.L., Yu S.C.H., Ng K.K.C., Lai P.B.S.
    Prospective double-blinded randomized controlled trial of microwave versus radiofrequency ablation for hepatocellular carcinoma (McRFA trial).
    HPB 2020 (in press)

  • Xu F, Li CH, Wong CH, Chen GG, Lai PBS, Shao S, Chan SL, Chen Y.
    Genome-Wide Screening and Functional Analysis Identifies Tumor Suppressor Long Noncoding RNAs Epigenetically Silenced in Hepatocellular Carcinoma.
    Cancer Res. 2019 Apr 1;79(7):1305-1317. doi: 10.1158/0008-5472.CAN-18-1659.
  • Xiong L, Wu F, Wu Q, Xu L, Cheung OK, Kang W, Mok MT, Szeto LLM, Lun CY, Lung RW, Zhang J, Yu KH, Lee SD, Huang G, Wang CM, Liu J, Yu Z, Yu DY, Chou JL, Huang WH, Feng B, Cheung YS, Lai PB, Tan P, Wong N, Chan MW, Huang TH, Yip KY, Cheng AS, To KF.
    Aberrant enhancer hypomethylation contributes to hepatic carcinogenesis through global transcriptional reprogramming.
    Nat Commun. 2019 Jan 18;10(1):335. doi: 10.1038/s41467-018-08245-z.
  • Wong TC, Ng KK.
    ASO Author reflections: Liver transplantation for hepatocellular carcinoma
    Annals of Surgical Oncology 2019; 26: 1463 - 64
  • Wong TC, Ng KK, Fung JY, Chan AC, Cheung TT, Chok KS, Dai JW, Lo CM.
    Long-term survival outcome between living donor and deceased donor liver transplant for hepatocellular carcinoma: Intention-to-treat and propensity score matching analyses.
    Annals of Surgical Oncology 2019; 26: 1454 - 62
  • Wong SS, Yuen BT, Lee RK, Tsai CS, Cheung YS, Lee KF, Yu SCH.
    Percutaneous Portal Vein Embolization Using a Simplified Sheathless 18-Gauge Trocar Needle Approach: Review of Efficacy and Safety.
    J Vasc Interv Radiol. 2019;30:440-444
  • Wong LCH, Lee KF, Lai PBS, Chong CCN.
    Superior mesenteric venous thrombophlebitis: a rare complication of a common disease.
    Surgical Practice 2019;23:28-30
  • Wong HCY, Lam KY, Chong CCN, Chan AWH, Chan SL.
    Impact of Weight Loss During Chemotherapy in Chinese Patients with Unresectable Pancreatic Cancer.
    Nutr Cancer. 2019;71(6):954-970. doi: 10.1080/01635581.2019.1595047.
  • Tian Y, Yang B, Qiu W, Hao Y, Zhang Z, Yang B, Li N, Cheng S, Lin Z, Rui YC, Cheung OKW, Yang W, Wu WKK, Cheung YS, Lai PBS, Luo J, Sung JJY, Chen R, Wang HY, Cheng ASL, Yang P.
    ER-residential Nogo-B accelerates NAFLD-associated HCC mediated by metabolic reprogramming of oxLDL lipophagy.
    Nat Commun. 2019 Jul 29;10(1):3391. doi: 10.1038/s41467-019-11274-x.
  • Sun K, Jiang P, Cheng SH, Cheng THT, Wong J, Wong VWS, Ng SSM, Ma BBY, Leung TY, Chan SL, Mok TSK, Lai PBS, Chan HLY, Sun H, Chan KCA, Chiu RWK, Lo YMD.
    Orientation-aware plasma cell-free DNA fragmentation analysis in open chromatin regions informs tissue of origin.
    Genome Res. 2019 Mar;29(3):418-427. doi: 10.1101/gr.242719.118.
  • Song C, Ma X, Xia X, Chiu PWY, Chong CCN, Li Z.
    A robotic flexible endoscope with shared autonomy: a study of mockup cholecystectomy.
    Surg Endosc. 2019 Nov 13. doi: 10.1007/s00464-019-07241-8.
  • Shi L, Zhang SJ, Chen J, Lu SX, Fan XJ, Tong JH, Chow C, Tin EK, Chan SL, Chong CC, Lai PB, To KF, Wong N, Chan AW.
    A comparability study of immunohistochemical assays for PD-L1 expression in hepatocellular carcinoma.
    Mod Pathol. 2019 Jun 23. doi: 10.1038/s41379-019-0307-8.
  • Qiu SY, Ng KK, Cheung TT, Liu CH, Zhu HT, Xu BR, Ji R, Lo CM.
    A successful combined laparoscopic cholecystectomy and laparoscopic exploration of common bile duct for acute gangrenous cholecystitis and choledocholithiasis during pregnancy: A case report.
    International Journal of Surgery Case Report 2019; 58: 14 - 17
  • Qiu SY, Ng KK, Cheung TT, Ji R, Liu CH, Zhu HT, Xu BR, Lo CM.
    Applications of surgical techniques of living donor liver transplantation in complex hepatic resection for hepatocellular carcinoma.
    Surgical Practice 2019; 23: 121 - 22
  • Ng KK, Cheung TT, Wong TC, Fung JY, Dai JW, Ma KW, She WH, Lo CM.
    Long-term survival comparison between primary transplant and upfront curative treatment with salvage transplant for early stage hepatocellular carcinoma.
    Asian Journal of Surgery 2019; 42: 433 - 42
  • Ng KK, Cheung TT, Pang HH, Wong TC, Dai JW, Ma KW, She WH, Kotewall CN, Lo CM.
    A simplified prediction model for early intrahepatic recurrence after hepatectomy for patients with unilobar hepatocellular carcinoma without macrovascular invasion: An implication for adjuvant therapy and postoperative surveillance.
    Surgical Oncology 2019; 30: 6 - 12
  • Ma M-J.L., Zhang H., Jiang P., Sin S.T.K., Lam W.K.J., Cheng S.H., Lee W-S., Gai W, Tse O.Y.O., Peng W., Wong J., Raghupathy R., Wong R.S.M., Sahota D., Leung T.Y., Chan K.C.A., Chiu R.W.K., Lo Y.M.D.
    Topologic analysis of plasma mitochondrial DNA reveals the coexistence of both linear and circular molecules.
    Clinical Chemistry 2019;65(9):1161-1170
  • Liu R, Wakabayashi G, Palanivelu C, Tsung A, Yang K, Goh BKP, Chong CC, Kang CM, Peng C, Kakiashvili E, Han HS, Kim HJ, He J, Lee JH, Takaori K, Marino MV, Wang SN, Guo T, Hackert T, Huang TS, Anusak Y, Fong Y, Nagakawa Y, Shyr YM, Wu YM, Zhao Y.
    International consensus statement on robotic pancreatic surgery.
    Hepatobiliary Surg Nutr. 2019 Aug;8(4):345-360. doi: 10.21037/hbsn.2019.07.08.
  • Li L, Chan SL, Mo F, Hui EP, Koh J, Chan AKC, Tang NLS, Lee KF, Lai PBS, Yu SCH, Yeo W.
    Correlations of health-related quality of life with serum inflammatory indicators IL-8 and mIBI in patients with hepatocellular carcinoma.
    Cancer Management and Research 2019;11:2719–2727
  • Li L, Chan SL, Mo F, Hui EP, Koh J, Chan AK, Tang NL, Chu CM, Hui J, Lee KF, Yu S, Yeo W.
    Status of inflammation in relation to health related quality of life in hepatocellular carcinoma patients.
    Qual Life Res. 2019 Apr 29. doi: 10.1007/s11136-019-02190-0.
  • Lee K.F., Lok H.T., Fung A.K.Y., Chong C.C.N., Cheung Y.S., Wong J., Lai P.B.S.
    Successful robotic extirpation of diaphragmatic seeding of hepatocellular carcinoma after previous rupture.
    Journal of Robotic Surgery 2019;13:525-528
  • Lee K.F., Chong C.C.N., Cheung S.Y.S., Wong J., Fung A.K.Y., Lok H.T., Lai P.B.S.
    Impact of intermittent Pringle maneuver on long-term survival after hepatectomy for hepatocellular carcinoma: result from two combined randomized controlled trials.
    World Journal of Surgery 2019;43:3101-3109
  • FUNG, Andrew Kai Yip; CHONG, Charing Ching Ning.
    Surgical strategy for neuroendocrine liver metastases.
    Surgical Practice. 2019;23(2): 59-67.
  • Fung SW, Cheung PF, Yip CW, Ng LW, Cheung TT, Chong CC, Lee C, Lai PB, ChanAW, Tsao GS, Wong CH, Chan SL, Lo KW, Cheung ST.
    The ATP-binding cassette transporter ABCF1 is a hepatic on cofetal protein that promotes chemoresistance, EMT and cancer stemness in hepatocellular carcinoma.
    Cancer Lett. 2019 Aug10;457:98-109. doi: 10.1016/j.canlet.2019.05.010.
  • Fung AKY, Lee KF.
    Robotic resection for posterosuperior liver lesions: is it really superior to laparscopic resection?
    Hepatobiliary Surg Nutr 2019;8(3):264-266.
  • Fung AKY, Lee KF, Chong CCN, Lai PBS.
    Robotic cholecystectomy for duplicated gallbladder.
    Scottish Medical Journal 2019;64:112-115.
  • Dupré A, Berhane S, Chan AWH, Rivoire M, Chong CCN, Lai PBS, Cucchetti A, Poston GJ, Malik HZ, Johnson PJ.
    Multicentre validation of a clinical prognostic score integrating the systemic inflammatory response to the host for patients treated with curative-intent for colorectal liver metastases: The Liverpool score.
    Eur J Surg Oncol. 2019 Jun;45(6):999-1004. doi: 10.1016/j.ejso.2019.02.022.
  • Ding X, He M, Chan AWH, Song QX, Sze SC, Chen H, Man MKH, Man K, Chan SL, Lai PBS, Wang X, Wong N.
    Genomic and Epigenomic Features of Primary and Recurrent Hepatocellular Carcinomas.
    Gastroenterology. 2019 Dec;157(6):1630-1645.e6. doi: 10.1053/j.gastro.2019.09.005.
  • Deng M, Ng SWY, Cheung ST, Chong CCN.
    Clinical application of Albumin-Bilirubin (ALBI) score: The current status.
    Surgeon. 2019 Oct 8. pii:S1479-666X(19)30116-7. doi: 10.1016/j.surge.2019.09.002.
  • Chong, Charing Ching Ning.
    Stay Hungry. Stay Foolish.
    Surgical Practice. 2019;23(2):36. doi: 10.1111/1744-1633.12374.
  • Chong CC, Lee KF, Chu CM, Chan AW, Yu SC, Lai PB.
    Laparoscopic Hepatectomy (with or without Robotic Assistance) versus Radiofrequency Ablation as a Minimally Invasive Treatment for Very Early-Stage or Early-Stage Hepatocellular Carcinoma.
    Dig Surg. 2019 Mar 27:1-7. doi: 10.1159/000497112.
  • Chong C.C.N., Chung W.Y., Cheung Y.S., Fung A.K.Y., Fong A.K.W., Lok H.T., Wong J., Lee K.F., Chan S.K.C., Lai P.B.S.
    Enhanced recovery after surgery for liver resection.
    Hong Kong Medical Journal 2019;25(2);94-101
  • Cheung YS, Fung AS, Lai PB.
    Determining the surgical quality improvement model by outcome monitoring in Hong Kong public hospitals.
    Surg Pract. 2019 Aug 19.
  • CHAN, Wai Lok; CHONG, Ching Ning.
    Macrocystic variant of serous cystadenoma of the pancreas mimicking mucinous neoplasm of the pancreas.
    Surgical Practice. 2019;23(2):79-80.
  • Chan AW, Zhang Z, Chong CC, Tin EK, Chow C, Wong N.
    Genomic landscape of lymphoepithelioma-like hepatocellular carcinoma.
    J Pathol. 2019 Jun 5. doi: 10.1002/path.5313.
  • Zhou J, Liu M, Sun H, Feng Y, Xu L, Chan AWH, Tong JH, Wong J, Chong CCN, Lai PBS, Wang HK, Tsang SW, Goodwin T, Liu R, Huang L, Chen Z, Sung JJ, Chow KL, To KF, Cheng AS.
    Hepatoma-intrinsic CCRK inhibition diminishes myeloid-derived suppressor cell immunosuppression and enhances immune-checkpoint blockade efficacy.
    Gut. 2018 May;67(5):931-944. doi: 10.1136/gutjnl-2017-314032.
  • Yuen WC, Wong K, Cheung YS, Lai PB.
    Reduction of operative mortality after implementation of Surgical Outcomes Monitoring and Improvement Program by Hong Kong Hospital Authority.
    Hong Kong Med J 2018;24:137-44.
  • Yu S.C.H., Chan S.L., Lee K.F., Hui J.W.Y., Hui E.P., Chu C.M., Chan A.W., Cheung S., Li L., Wong J., Yeo W.M.M.
    Ablative chemoembolization for hepatocellular carcinoma: A prospective phase I case-control comparison with conventional chemoembolization.
    Radiology 2018;287(1):340-348
  • Teoh AYB, Chong CCN, Leung WW, Chan SKC, Tse YK, Ng EKW, Lai PBS, Wu JCY, Lau JYW.
    Electroacupuncture-reduced sedative and analgesic requirements for diagnostic EUS: a prospective, randomized, double-blinded, sham-controlled study.
    Gastrointest Endosc. 2018 Feb;87(2):476-485. doi: 10.1016/j.gie.2017.07.029.
  • Tang PM, Zhou S, Li CJ, Liao J, Xiao J, Wang QM, Lian GY, Li J, Huang XR, To KF, Ng CF, Chong CC, Ma RC, Lee TL, Lan HY.
    The proto-oncogene tyrosine protein kinase Src is essential for macrophage-myofibroblast transition during renal scarring.
    Kidney Int. 2018 Jan;93(1):173-187. doi: 10.1016/j.kint.2017.07.026.
  • Sun H, Yang W, Tian Y, Zeng X, Zhou J, Mok MTS, Tang W, Feng Y, Xu L, Chan AWH, Tong JH, Cheung YS, Lai PBS, Wang HKS, Tsang SW, Chow KL, Hu M, Liu R, Huang L, Yang B, Yang P, To KF, Sung JJY, Wong GLH, Wong VWS, Cheng ASL.
    An inflammatory-CCRK circuitry drives mTORC1-dependent metabolic and immunosuppressive reprogramming in obesity-associated hepatocellular carcinoma.
    Nat Commun. 2018;9:5214.
  • Siu EHL, Ng SSM, Chan AWH, Lau JYW, Lo KW, Chong CCN, Lai PBS, Chan SL, Law MHN, Ng LWC, And Cheung ST.
    PD-L1 Expression Associated with Treatment Responses in Colorectal Cancer Patients with XELOX/FOLFOX Chemotherapy: Potential of Checkpoint Blockage and Natural Killer Cell-Based Immunotherapy.
    Cancer Res 2018; 78(13):4563–4563.
  • Siu EH, Chan AW, Chong CC, Chan SL, Lo KW, Cheung ST.
    Treatment of advanced hepatocellular carcinoma: immunotherapy from checkpoint blockade to potential of cellular treatment.
    Transl Gastroenterol Hepatol. 2018 Nov 7;3:89. doi: 10.21037/tgh.2018.10.16.
  • Niu LL, Cheng CL, Li MY, Yang SL, Hu BG, Chong CCN, Chan SL, Ren J, Chen GG, Lai PBS.
    ID1-induced p16/IL6 axis activation contributes to the resistant of hepatocellular carcinoma cells to sorafenib.
    Cell Death Dis. 2018 Aug 28;9(9):852. doi: 10.1038/s41419-018-0926-x.
  • Lee YY, Mok MT, Kang W, Yang W, Tang W, Wu F, Xu L, Yan M, Yu Z, Lee SD, Tong JH, Cheung YS, Lai PB, Yu DY, Wang Q, Wong GL, Chan AM, Yip KY, To KF, Cheng AS.
    Loss of tumor suppressor IGFBP4 drives epigenetic reprogramming in hepatic carcinogenesis.
    Nucleic Acids Res. 2018 Jul 10. [Epub ahead of print]
  • Lee KF.
    Mirizzi syndrome: a new approach to an old problem.
    Hepatobiliary Surg Nutr 2018;7:56-57
  • Lee KF, Fung AK, Lok HT, Fong AK, Chong CC, Lai PB.
    Robot-assisted minimally invasive procedures for complicated biliary stone disease.
    Hepatobiliary Surg Nutr. 2018;7(3):185-188. doi: 10.21037/hbsn.2017.05.12.
  • Lee K.F., Wong J., Cheung S.Y.S., Chong C.C.N., Hui J.W.Y., Leung V.Y.F., Yu S.C.H., Lai P.B.S.
    Does intermittent Pringle maneuver increase postoperative complications after hepatectomy for hepatocellular carcinoma? A randomized controlled trial.
    World Journal of Surgery 2018 Oct;42(10):3302-3311
  • Lee K.F., Chong C.C.N., Fong A.K.W., Fung A.K.Y, Lok H.T., Cheung Y.S., Wong J., Lai P.B.S.
    Pattern of disease recurrence and its implications for postoperative surveillance after curative hepatectomy for hepatocellular carcinoma: experience from a single center.
    HepatoBiliary Surgery and Nutrition 2018;7(5):320-330
  • Jiang P., Sun K., Tong Y.K., Cheng S.H., Cheng T.H.T., Heung M.M.S., Wong J., Wong V.W.S., Chan H.L.Y., Chan K.C.A., Lo Y.M.D., Chiu R.W.K.
    Preferred end coordinates and somatic variants as signatures of circulating tumor DNA associated with hepatocellular carcinoma.
    Proceedings of the Academy of Sciences 2018 Nov 13, 115(46) E10925-E10933
  • Gai W., Ji L., Lam W.K.J., Sun K., Jiang P., Chan A.W.H., Wong J., Lai P.B.S., Ng S.S.M., Ma B.B.Y., Wong G.L.H., Wong V., Chan H.L.Y., Chiu R.W.K., Lo Y.M., Chan K.C.A.
    Liver- and colon-specific DNA methylation markers in plasma for investigation of colorectal cancers with or without liver metastases.
    Clinical Chemistry 2018 Aug; 64(8):1239-1249
  • Dogeas E, Chong CCN, Weiss MJ, Ahuja N, Choti MA.
    Can echogenic appearance of neuroendocrine liver metastases on intraoperative ultrasonography predict tumor biology and prognosis?
    HPB (Oxford). 2018 Mar;20(3):237-243. doi: 10.1016/j.hpb.2017.08.029.
  • Chung PH, Ng KK, Wong TC, Sin SL, Lo CM.
    An innovative rescue surgical procedure for early-onset hepatic venous outflow obstruction after pediatric living-donor liver transplantation.
    Liver Transplantation 2018; 24: 1765 - 68
  • Chong CCN.
    Pattern, timing, and predictors of recurrence following pancreatectomy for pancreatic ductal adenocarcinoma: how do they matter?
    J Vis Surg. 2018 May 18;4:106. doi: 10.21037/jovs.2018.05.14.
  • Chong CC.
    Pros and cons of clinical practice based on guidelines.
    Hong Kong Med J. 2018 Oct;24(5):440-441. doi: 10.12809/hkmj185083.
  • Chong C.C.N., Chan A.W.H., Wong J., Chu C.M., Chan S.L., Lee K.F., Yu S.C.H., To K.F., Johnson P., Lai P.B.S.
    Albumin-bilirubin grade predicts the outcomes of liver resection versus radiofrequency ablation for very early/ early stage of hepatocellular carcinoma.
    The Surgeon 2018 Jun;16(3):163-170
  • Cheung TT, Kwok PC, Chan S, Cheung CC, Lee AS, Lee V, Cheng HC, Chia NH, Chong CCN, Lai TW, Law ALY, Luk MY, Tong CC, Yau TCC.
    Hong Kong Consensus Statements for the Management of Unresectable Hepatocellular Carcinoma.
    Liver Cancer. 2018 Mar;7(1):40-54. doi: 10.1159/000485984.
  • Cheung TT, Han HS, She WH, Chen KH, Chow PKH, Yoong BK, Lee KF, Kubo S, Tang CN, Wakabayashi G.
    The Asia Pacific Consensus Statement on laparoscopic liver resection for hepatocellular carcinoma: a report from the 7th Asia-Pacific Primary Liver Cancer Expert Meeting Held in Hong Kong.
    Liver Cancer 2018;7:28-39
  • Chan AWH, Zhong J, Berhane S, Toyoda H, Cucchetti A, Shi K, Tada T, Chong CCN, Xiang BD, Li LQ, Lai PBS. Mazzaferro V, García-Fiñana M, Kudo M, Kumada T, Roayaie S, Johnson PJ.
    Development of pre and post-operative models to predict early recurrence of hepatocellular carcinoma after surgical resection.
    J Hepatol. 2018 Dec;69(6):1284-1293. doi: 10.1016/j.jhep.2018.08.027.
  • Teoh AYB, Serna C, Penas I, Chong CCN, Perez-Miranda M, Ng EKW, Lau JYW.
    Endoscopic ultrasound-guided gallbladder drainage reduces adverse events compared with percutaneous cholecystostomy in patients who are unfit for cholecystectomy.
    Endoscopy. 2017 Feb;49(2):130-138. doi: 10.1055/s-0042-119036.
  • Ng KK, Chok KS, Chan AC, Cheung TT, Wong TC, Fung JY, Yuen J, Poon RT, Fan ST, Lo CM.
    Randomized trial of hepatic resection versus radiofrequency ablation for early stage hepatocellular carcinoma.
    British Journal of Surgery 2017; 104: 1775 - 1784
  • Lok H.T., Chong C.N., Chan A.W.H., Fong K.W., Cheung Y.S., Wong J., Lee K.F., Lai P.B.S.
    Primary hepatic gastrointestinal stromal tumor presented with rupture.
    HepatoBiliary Surg Nutr (Images in Clinical Medicine) 2017;6(1):65-66
  • Li L, Mo FK, Chan SL, Hui EP, Tang NS, Koh J, Leung LK, Poon AN, Hui J, Chu CM, Lee KF, Ma BB, Lai PB, Chan AT, Yu SC, Yeo W.
    Progostic values of EORTC QLQ-C30 and QLQ-HCC18 index-scores in patients with hepatocellular carcinoma-clinical application of health-related quality-of-life data.
    BMC Cancer 2017;17:8
  • Lee K.F., Wong J., Hui J.W., Cheung Y.S., Chong C.C., Fong A.K., Yu S.C., Lai P.B.
    Long-term outcomes of microwave versus radiofrequency ablation for hepatocellular carcinoma by surgical approach: A retrospective comparative study.
    Asian Journal of Surgery 2017;40:301-308
  • Lam PK, Chong CCN, Lo AWI, Chan AWH, Tong CSW, Chin DWC, Wong KHK, Choy RKW, Fung AK, Wang YX, To KF, Lai PBS.
    Topical Application of Mesenchymal Stromal Cells Ameliorated Liver Parenchyma Damage After Ischemia-Reperfusion Injury in an Animal Model.
    Transplant Direct. 2017 May 11;3(6):e160. doi: 10.1097/TXD.0000000000000675. eCollection 2017 Jun.
  • Lam KY, Lee K, Chong C, Chan AWH, Mok T, Chan SL.
    A Study on Thromboembolism of Patients with Pancreatic Cancer.
    J Clin Oncol 2017; 35(4): 262.
  • KF Lee, CCN Chong, JHH Yeung, NK Cheung, EYY Siu, YS Cheung, J Wong, PBS Lai.
    Factors affecting outcomes in traumatic liver injury: A retrospective study.
    Surgical Practice 2017;21:63-69
  • Fung A.K.Y., Chong C.C.N., Lee K.F., Wong J., Cheung Y.S., Fong A.K.W., Lai P.B.S.
    Outcomes of emergency and interval hepatectomy for ruptured resectable hepatocellular carcinoma: a single tertiary referral centre experience.
    Hepatoma Research 2017;3:196-204
  • Chong CC, Wong GL, Chan AW, Wong VW, Fong AK, Cheung YS, Wong J, Lee KF, Chan SL, Lai PB, Chan HL.
    Liver stiffness measurement predicts high-grade post-hepatectomy liver failure: A prospective cohort study.
    J Gastroenterol Hepatol. 2017 Feb;32(2):506-514. doi: 10.1111/jgh.13503.
  • Chan SL, Yeo W, Mo F, Chan AWH, Koh J, Li L, Hui EP, Chong CCN, Lai PBS, Mok TSK, Yu SCH.
    A phase 2 study of the efficacy and biomarker on the combination of transarterial chemoembolization and axitinib in the treatment of inoperable hepatocellular carcinoma.
    Cancer. 2017 Oct 15;123(20):3977-3985. doi: 10.1002/cncr.30825.
  • Chan SL, Chan AW, Chan AK, Jian P, Mo F, Chan CM, Mok K, Liu C, Chong CC, Chan AT, Mok T, Yeo W.
    Systematic evaluation of circulating inflammatory markers for hepatocellular carcinoma.
    Liver Int. 2017 Feb;37(2):280-289. doi: 10.1111/liv.13218.
  • Chan AWH, Leung HHW, Chong CCN, Chan SL.
    Validating the ALBI grade: Its current and future use in HCC prognostication.
    J Hepatol. 2017 Mar;66(3):661-663. doi: 10.1016/j.jhep.2016.10.037.
  • Chan A.W. Chong C.C., Mo F.K., Wong J., Yeo W., Johnson P.J., Yu S., Lai P.B., Chan A.T., To K.F., Chan S L.
    Incorporating albumin-bilirubin grade into the cancer of the liver Italian program system for hepatocellular carcinoma.
    Journal of Gastroenterology and Hepatology 2017;32:221-228
  • Anthony W.H. Chan, Charing C.N. Chong, Paul B.S. Lai, Winnie Yeo, Ka Fai To, and Stephen Lam Chan.
    A novel and validated inflammation-integrated prognostic model for hepatocellular carcinoma (HCC).
    J Clin Oncol. 2017 35:15_suppl, e15679-e15679.

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