Dr XIA Xianfeng Derek    
夏賢峰

0000-0003-4718-8189

Biography

Dr. Xianfeng Xia is an Assistant Professor in the Department of Surgery at Faculty of Medicine, The Chinese University of Hong Kong (CUHK). He obtained his PhD from the Department of Surgery, CUHK in 2017 and completed a Postdoctoral Research Fellowship (2017-2019) at the Chow Yuk Ho Technology Center for Innovative Medicine, CUHK. Before joining CUHK as a faculty, Dr. Xia was the Associate Chief Physician and Research Assistant Professor at Sun Yat-sen University Cancer Center.

Dr. Xia's research focuses on unraveling the mechanisms underlying gastrointestinal (GI) mucosal injury and its associated complications caused by various factors, including autoimmune disorders, drugs, chemoradiotherapy, and endoscopic resection, while developing innovative treatments using advanced biomaterials and regenerative medicine. His work has been published in leading journals such as Science Translational Medicine, Science Advances, Nature Communications, and Advanced Functional Materials. Recently, his team has expanded research on immunotherapy resistance in GI cancers and developing bioinspired nanomedicines to address these challenges. Dr. Xia has secured competitive external grants as PI from the Natural Science Foundation of China and the Guangdong Basic and Applied Basic Research Foundation. He is currently the young editorial member for the journal Extracellular Vesicle and serves as the member of the Committee of Endoscopology, Guangdong Provincial Anticancer Association.

Research Interests

• Novel Endoscopic Technologies for Diagnosis and Treatment of Early GI Cancers
• Therapeutic Exosomes and Biomaterials for GI Application
• Cancer Immunotherapy Resistance

Additional Information

Awards:

• Best Paper, 2020 Chinese Conference of Digestive Endoscopology (09/2020)
• Young Investigator Award Presentation, The International Digestive Disease Forum, Hong Kong (08/2018)
• Travel Grant, Asian Pacific Digestive Disease Week (APDW) Kobe, Japan (10/2016)
• Outstanding Abstract Award, International Minimally Invasive Surgery Conference, Hong Kong (08/2015)

1. 2024-2026, Guangdong Basic and Applied Basic Research Fund, Principal Investigator (RMB 300,000)
2. 2023, Fundamental Research Funds for the Central Universities, Principal Investigator (RMB 50,000)
3. 2022-2023, Guangdong Science and Technology Bureau, Principal Investigator (RMB 50,000)
4. 2021-2023, Natural Science Foundation of China, Principal Investigator (RMB 240,000)
5. 2020-2021, Guangdong Basic and Applied Basic Research Fund, Principal Investigator (RMB 100,000)

Selected Publications

1. Lai H, Yip HC, Gong Y, Chan KF, Leung KK, Chan MS, Xia X#, Chiu PWY#, MFGE8 in exosomes derived from mesenchymal stem cells prevents esophageal stricture after endoscopic submucosal dissection in pigs. Journal of Nanobiotechnology,2024, 22:143.
2. Xia X*, Xu X*, Wang B, Zhou D, Zhang W, Xie X, Lai H, Xue J, Rai A, Li Z, Peng X, Zhao P, Bian L, Chiu PWY, Adhesive hemostatic hydrogel with ultrafast gelation arrests acute upper gastrointestinal hemorrhage in pigs. Advanced Functional Materials, 2022, 32.16: 2109332.
3. Xia X*, Chan KF*, Wong GTY, Wang P, Liu L, Yeung BPM, Ng EKW, Lau JYW, Chiu PWY, Mesenchymal stem cells promote healing of nonsteroidal anti-inflammatory drug-related peptic ulcer through paracrine actions in pigs. Science Translational Medicine, 2019, 11(516):aat7455.
4. Zhao P*, Xia X*, Xu X*, Leung KC, Rai A, Deng Y, Yang B, Lai H, Peng X, Peng S, Zhang H, Chiu PWY, Bian L. Nanoparticle-assembled bioadhesive coacervate coating with prolonged gastrointestinal retention for inflammatory bowel disease therapy. Nature Communications, 2021, 12:7162.
5. Peng X*, Xia X*, Xu X*, Yang X, Yang B, Zhao P, Yuan W, Chiu PWY, Bian L. Ultra-fast self-gelling powder mediate robust wet adhesion to promote healing of gastrointestinal perforations. Science Advances, 2021, 7(23): eabe8739.
6. Peng X, Xu X, Deng Y, Xie X, Xu L, Xu X, Yuan W, Yang B, Yang X, Xia X#, Duan L#, Bian L#. Ultra-fast self-gelling and wet adhesive powder for acute hemostasis and wound healing. Advanced Functional Materials, 2021, 2102583.
7. Xu X*, Xia X*, Zhang K*, Rai A, Li Z, Zhao PC, Wei KC, Zou L, Yang BG, Wong WK, Chiu PWY, Bian L. Bioadhesive hydrogels demonstrating pH-independent and ultrafast gelation promote gastric ulcer healing in pigs. Science Translational Medicine, 2020, 12(558):aba8014.
8. Yu J, Xia X, Dong Y, Gong Z, Li G, Chen GG, Lai PBS. CYP1A2 suppresses hepatocellular carcinoma through antagonizing HGF/MET signaling. Theranostics, 2021; 11(5):2123-2136.
9. Wang B, Chan KF, Yuan K, Wang Q, Xia X, Yang L, Ko H, Wang YJ, Sung JJY, Chiu PWY, Zhang L. Endoscopy-assisted magnetic navigation of biohybrid soft microrobots with rapid endoluminal delivery and imaging. Science Robotics 2021, 6(52): eabd2813.
10. Chiu PWY, Yip HC, Xia X, Chan SM, Ng EKW, Lau JYW. How I do it: Flexible 3‐D endoscope for endoscopic submucosal dissection. Digestive Endoscopy, 2019, 31(3): 323-328.
11. Xia X, Chiu PWY, Lam PK, Chin WC, Ng EKW, Lau JYW. Secretome from hypoxia-conditioned adipose-derived mesenchymal stem cells promotes the healing of gastric mucosal injury in a rodent model. Biochimica et Biophysica Acta - Molecular Basis of Disease, 2018, 1864(1): 178-188. (IF: 6.2)
12. Xia X, Chiu PWY, Tsoi KKF, Chan FKL, Sung JJY, Lau JYW. The effect of off-hours hospital admission on mortality and clinical outcomes for patients with upper gastrointestinal hemorrhage: A systematic review and meta-analysis of 20 cohorts. United European Gastroenterology Journal, 2018, 6(3): 367-381. (IF: 6.0)
13. Xia X, Chiu PWY. Endoscopic resection for early gastric cancer: The current controversies. Gastrointestinal Intervention, 2016, 5(1): 1-5.