Department of Surgery, CUHK

Dr LI Linxian    

Associate Professor

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Dr. Linxian Li is a biomedical engineer with interdisciplinary expertise in lipid chemistry, drug formulation, and pharmaceutical engineering. Dr. Li obtained his PhD degree at University of Heidelberg in Germany, and he pursued postdoctoral research at Massachusetts Institute of Technology. He focuses on developing lipid nanoparticles to deliver mRNA therapeutics. In 2017, Dr. Li was among the first batch of young Chinese researchers to receive the MIT Technology Review Innovators Under 35 Awards. He was listed as a pioneer for exploring the therapeutic potentials of human messenger RNA (mRNA). His work has resulted in papers, patents and patent applications. These patents have been licensed to chemical and biotechnology companies, and several products that have been commercialized.

Research Interests

  • mRNA delivery

Additional Information

  • Fortune China 40 Under 40 2023
  • MIT Technology Review Innovators Under 35 China 2017

Selected Publications

  1. Li, F., Han, J., Cao, T., Lam, W., Fan, B., Tang, W., Chen, S., Fok, K. L., & Li, L. (2019). Design of self-assembly dipeptide hydrogels and machine learning via their chemical features. Proceedings of the National Academy of Sciences, 116(23), 11259–11264.
  2. Miao, L., Li, L., Huang, Y., Delcassian, D., Chahal, J., Han, J., Shi, Y., Sadtler, K., Gao, W., Lin, J., Doloff, J. C., Langer, R., & Anderson, D. G. (2019). Delivery of mRNA vaccines with heterocyclic lipids increases anti-tumor efficacy by STING-mediated immune cell activation. Nature Biotechnology, 37(10), 1174–1185.
  3. Li, L., Wang, F., Wu, Y., Davidson, G., Levkin, P.A. (2013). Combinatorial synthesis and high-throughput screening of alkyl amines for nonviral gene delivery. Bioconjugate Chemistry, 24(9), 1543-1551.
  4. Li, L., Zahner, D., Su, Yi., Gruen, C., Davidson, G., Levkin, P.A. (2012). A biomimetic lipid library for gene delivery through thiol-yne click chemistry. Biomaterials, 33(32), 8160-8166.

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