Department of Surgery, CUHK

Dr LIAO Rui    

Research Assistant Professor

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Dr. Liao is a Research Assistant Professor in Department of Surgery at The Chinese University of Hong Kong. She completed her PhD study in the University of Chinese Academy of Sciences in 2021 and received her postdoctoral training at Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences in Guangzhou, China.

Dr. Liao specializes in tumor immunotherapy, with a particular focus on chimeric antigen receptor (CAR)-T cell therapy and induced-T-to-natural killer (ITNK) cell therapy. Alongside her colleagues, they are committed to developing and optimizing new CAR-T and ITNK cells for the treatment of leukemia and solid tumors.

Research Interests

  • Optimization of CAR vector designs
  • Metabolic-epigenetic regulation of CAR-T and ITNK cells

Additional Information

Guangzhou Science and Technology Department, Guangzhou General Project, 2023A04J0103, Mechanistic study on IL-6/GP130/STAT3 signaling promoting CAR-T cell memory formation by regulating mitochondrial metabolism, 2023.04-2025.03

Awards and Honors:
The Second Prize of Outstanding Graduate Scholarship of GIBH (2021) The First-academic scholarship (2020)

Selected Publications

  1. Liao R*, Wu Y*, Le Q, Jiang Z, Gou S, Zhou L, Hong Q, Li Y, Shi J, Yao Y, Lai L, Li Y, Liu P, Thiery J, Qin D, Graf T, Liu X#, Li P#. BCL11B and the NuRD complex cooperatively guard T-cell fate and inhibit OPA1-mediated mitochondrial fusion in T cells. EMBO J. 2023.
  2. Jiang Z*, Qin L*, Tang Y*, Liao R, Shi J, He B, Li S, Zheng D, Cui Y, Wu Q, Long Y, Yao Y, Wei Z, Hong Q, Wu Y, Mai Y, Gou S, Li X, Weinkove R, Norton S, Luo W, Feng W, Zhou H, Liu Q, Chen J, Lai L, Chen X, Pei D, Graf T, Liu X, Li Y, Liu P#, Zhang Z#, Li P#. Human induced-T-to-natural killer cells have potent anti-tumor activities. Biomark Res. 2022 Mar 24;10(1):13.
  3. Jiang Z*, Liao R*, Lv J*, Li S, Zheng D, Qin L, Wu D, Chen S, Long Y, Wu Q, Wang S, Lin S, Huang X, Tang Z, Shi P, Zhou H, Liu Q, Zhao R, Li Y, Jie Y, Wei W, Lai P, Du X, Cui S, Weinkove R, Liu P, Pei D, Yao Y#, Li P#. IL-6 trans-signaling promotes the expansion and anti-tumor activity of CAR-T cells. Leukemia. 2020 May;35(5):1380-1391.

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