Dr DONG Yujuan Celia    
董鈺娟

Research Assistant Professor

Colorectal Surgery
(852) 3505 1209
yjdongadd this for spam@add this for spamsurgery.cuhk.edu.hk
AAS-3467-2021
0000-0003-0457-0337

Biography

Dr. Yujuan DONG is a Research Assistant Professor in Department of Surgery at The Chinese University of Hong Kong (CUHK). She completed her Ph.D. in the Department of Surgery at CUHK in 2012 and received post-doctoral training in State Key Laboratory of Digestive Disease, CUHK (2013-2018). She was a visiting scientist in Erasmus University Medical Center, Netherlands in 2018. She has published 36 papers in peer-reviewed journals (8 of them as the first or co-first), including papers in Cancer Research, Theranostics, Oncogene, Molecular Cancer and Journal of Pathology.

As Principal Investigator, Dr. DONG obtained two NSFC grants (NSFC General Program and Young scientist program). She is a Co-I of Lim Peng Suan Charitable Trust Research Fund and key team member of National Key Research and Development Program of China (2018). Dr. DONG has received several awards including Young Investigator Award in The 13th International Gastrointestinal Consensus Symposium 2013 (Japan) and Basis Science Travel Grants in United European Gastroenterology Week (2016 and 2017). Her current research focuses on the mRNA isoform switch and epigenetic regulation of colorectal cancer.

Research Interests

• mRNA isoform switch in colorectal cancer
• Epigenetic regulation of tumor cells
• Wnt signaling pathways in GI cancer

Additional Information

Grant:

• National Natural Science Foundation of China [PI; 2017] A study of the clinical significance and molecular mechanism of FOXF2 as a tumor suppressor in gastric cancer (81871900).
• National Natural Science Foundation of China [PI; 2019] A study of the clinical significance and molecular mechanism of VSTM2A as a tumor suppressor in colorectal cancer (81502436).
• Lim Peng Suan Charitable Trust Research Fund [Co-I; 2019] Prevention of Colorectal Cancer by Probiotics.

Award:

• Basis Science Travel Grant, United European Gastroenterology Week, 2016, Austria
• Basis Science Travel Grant, United European Gastroenterology Week, 2017, Spain
• Young Investigator Award, The 13th International Gastrointestinal Consensus Symposium, 2020, Japan

Selected Publications

1. Dong Y, Zhang Y, Kang W, Wang G, Chen H, Higashimori A, Nakatsu G, Go M, Tong JH, Zheng S, To KF, Sung JJ, Yang X, Ng SS, Yu J. VSTM2A suppresses colorectal cancer and antagonizes Wnt signaling receptor LRP6. Theranostics 2019,9:6517-6531. doi: 10.7150/thno.34989.
2. Higashimori A, Dong Y (co-first author), Zhang Y, Kang W, Nakatsu G, Ng SS, Arakawa T, Sung JJ, Chan FK, Yu J. Forkhead box F2 suppresses gastric cancer through a novel FOXF2-IRF2BPL-β-catenin signaling axis. Cancer Research 2018. doi: 10.1158/0008-5472.CAN-17-2403.
3. Zhang L, Dong Y (co-first author), Zhu N, Tsoi H, Zhao Z, Wu CW, Wang K, Zheng S, Ng SS, Chan FK, Sung JJ, Yu J. microRNA-139-5p exerts tumor suppressor function by targeting NOTCH1 in colorectal cancer. Molecular Cancer 2014,13:124.
4. Wang S, Dong Y (co-first author), Zhang Y, Wang X, Xu L, Yang S, Li X, Dong H, Xu L, Su L, Ng SS, Chang Z, Sung JJ, Zhang X, Yu J. DACT2 is a functional tumor suppressor through inhibiting Wnt/β-catenin pathway and associated with poor survival in colon cancer. Oncogene 2015,34:2575-85. doi: 10.1038/onc.2014.201.
5. Dong Y, Zhao J, Wu CW, Zhang L, Liu X, Kang W, Leung WW, Zhang N, Chan FK, Sung JJ, Ng SS, Yu J. Tumor Suppressor Functions of miR-133a in Colorectal Cancer. Molecular Cancer Research 2013,11:1051-60. doi: 10.1158/1541-7786.MCR-13-0061.